Juvederm vs Restylane (and Neuramis, EPTQ): Filler Brands Compared by Label and Official Sources

Which filler brand is best?

No source found ranks filler brands as best; what can be checked is which product is labelled for which area [1][7]. The US FDA says approved uses differ by product and that it may not have reviewed use in some locations of the body [1].

In the lab, commercial hyaluronic acid (HA) fillers differ widely in gel properties such as concentration, degree of cross-linking and particle size [11]. A 2024 study used NMR on 13 marketed HA fillers, including Restylane, Juvederm, Neuramis and EPTQ products, and found a wide range in the degree of modification (MoD) of the gel [10].

The authors of the 2024 study state that they recorded no clinical data or patient outcomes, so it cannot say how much the differences matter for results [10]. A 2009 paper concludes that gel properties should be read together with clinical experience when choosing a product [11].

This article therefore compares labels and checkable status, does not rank brands, and does not call any one the best. For the general picture of fillers, read [[what-is-filler]].

Juvederm vs Restylane: what differs on the label?

Juvederm vs Restylane is a comparison of two product families, each with several products that the FDA database lists for different areas, for example Restylane Kysse for the lips and Juvederm Voluma XC for the cheeks, chin and temples [4][6]. The database records Restylane under the applicant Q-Med AB and Juvederm under the applicant Allergan [7].

The table shows examples only, not a complete list, and the year is the year the FDA recorded the approval order for that use [3][4][5][6].

A name in the table does not mean the product is registered in Thailand for the same area. The Thai FDA (อย.) says each filler suits different areas and the details are on the label and the product leaflet [8]. For lip and chin, temple and nose specifics, read [[lip-filler]] and [[chin-temple-nose-filler]].

What is Neuramis?

Neuramis is a group of HA fillers that Medytox lists on its own website in 5 versions, and the name does not appear in the US FDA approval database [9][7]. The 2024 study of 13 fillers identifies its Neuramis Volume sample as made by Medy-Tox of Seoul [10].

The Medytox page lists Light Lidocaine, Lidocaine, Deep, Deep Lidocaine and Volume Lidocaine, calls them sterile single-use medical devices, and sends readers to the website of the MFDS, South Korea's regulator, for current approval details [9].

That page gives no indications and no US FDA status [9]. All 1,060 records the FDA database holds for product code LMH contain neither Neuramis nor Medytox [7].

So there is no US listing to compare. That does not mean unsafe; it means this article cannot cite a labelled area for Neuramis. In Thailand, ask the doctor for the registration number of the exact product and check it with the Thai FDA [8].

What is EPTQ?

EPTQ is the name of an HA filler that a 2024 study lists as made by Jetema of Seoul, and the name does not appear in the US FDA approval database [10][7]. That study analysed an Eptq S500 sample as one of its 13 fillers [10].

None of the 1,060 FDA records for product code LMH contains EPTQ or Jetema [7].

In the research for this article, no manufacturer or regulator page that could be opened confirmed the approval status, indications or registration number of EPTQ, so none is stated. The maker named in the sellers' listings that turned up did not agree between listings, so they were not used.

If a clinic offers EPTQ, ask for the Thai FDA registration number of the product to be used, check it with the Thai FDA, and photograph the product before treatment [8].

Can trial results of different brands be compared?

Not directly, because each company's trial uses its own rating scale, time point and participants [12][13].

Take two chin filler trials. One tested VYC-20L from Allergan on the ACRS scale and found 56.3% responders in the treated group against 27.5% in the control group at month 6 [12]. The other tested Restylane Defyne on a Galderma scale and found 81% responders against 6% in the control group at week 12 [13].

Those two numbers should not be set side by side to see which is better, because the rating scales differ, the time points differ, and both trials were paid for by the company that owns the product [12][13]. For chin filler, read [[chin-temple-nose-filler]].

What to check before choosing a filler brand

Check the product name, the area its label supports, the Thai FDA registration number and that the packaging is genuine [1][8]. The Thai FDA says fillers are medical devices that makers, importers and sellers must have licensed before sale, and advises checking the label, registration number, the Thai FDA website and QR code, and photographing the product [8].

The US FDA says counterfeit fillers have been marketed and used in the US [1]. It also warns that Juvederm Ultra 2, 3 and 4, sold through online retailers in the US, are not approved there and that their safety and effectiveness cannot be assured [2].

Questions to ask the doctor:

• Which exact product will be used, what is its Thai FDA registration number, and does its label support the area to be treated? [8][1]
• If the area is not in the label's indications, how does the doctor justify it and explain the risks? [1]
• May I see the box and label before it is opened, and photograph them? [8]
• If filler enters a blood vessel, what is the clinic's plan? [1]