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Results vary from person to person
Hyalase is a hyaluronidase injection from BMI KOREA Co., Ltd. of South Korea, in a box printed BM Hylunidase.
A hyaluronic acid filler may need correcting after a complication such as over-injection, uneven spread or a blocked blood vessel. Doctors use hyaluronidase to break down this type of filler.
A 2025 study in the Journal of Cosmetic Dermatology reports that the effect depends on the filler type, the concentration and the way the enzyme is given. Biphasic fillers break down faster than monophasic ones, and injecting into the filler itself works better than treating the skin surface. The type, amount and timing are therefore for the doctor to judge case by case.
Hyaluronidase is a protein and can cause allergic reactions, especially at high amounts. The 2025 study advises doctors to have antihistamines and steroids ready, and people with a history of allergy may need preparation before the drug is given.
Anyone considering treatment should tell the doctor about drug allergies, current medicines, and the type, brand, area and date of any filler injected before, so the doctor can decide for their own case.
BMI KOREA Co., Ltd. was founded in 2005 in South Korea and bought a GMP plant in the Hyangnam pharmaceutical complex in Hwaseong. It now has plants in Jeju and Cheongju. The company says it does business with countries in Europe, the Middle East, Africa, Asia (Thailand included) and the Americas.
Its pharmaceutical product pages list two hyaluronidase products, Hirax Inj. and BM Hyrunidase Inj. The second matches the Hyalase box.
It is an enzyme that breaks down hyaluronic acid, which is a different substance. Hyaluronic acid is found in body tissue and in some fillers. Once it is broken down, the tissue becomes less viscous and other substances pass through more easily. The human body makes five active forms; the medicine is produced separately.
In medicine it helps other drugs spread and pass through tissue faster, for example with local anaesthetic in eye surgery, in fluids given under the skin, and when some drugs leak out of a blood vessel. The maker, BMI, says it helps drugs injected under the skin or into muscle, and local anaesthetics, pass through tissue, and helps excess fluid and pooled blood in tissue to be reabsorbed.
No. It breaks down only hyaluronic acid fillers; other types are not broken down. Anyone who has had filler should tell the doctor which type and brand it was.
Of the hyaluronidases approved in the United States, three are extracted from animals and one is recombinant. Products from different companies can therefore differ, so read the leaflet that comes with the product.
The price depends on the model and the quantity.
This information is for general knowledge and does not replace a doctor's advice. Every procedure should be performed by a licensed doctor in a medical facility.

