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Results vary from person to person
Melsmon Placenta (Human) is an injectable solution of human placenta hydrolysate made by Melsmon Pharmaceutical of Japan, in 2 mL ampoules, 50 ampoules to the carton.
In Japan, Melsmon is a prescription-only medicine and is classed as a specified biological product (特定生物由来製品). The indications in the prescribing information are menopausal disorders and insufficient lactation.
This is label information for Japan. Who should receive the product, how much and for how long are decisions a doctor makes for each patient. The most recent prescribing information used here is the December 2023 revision.
According to the prescribing information, the maker uses human placentas collected in Japan. Donors are interviewed, blood is tested for viral and bacterial infection, and nucleic acid amplification tests (NAT) are run for HBV, HCV and HIV-1. Only placentas that pass are used.
A 2025 review in Frontiers in Pharmacology outlines the process: the umbilical cord is removed, blood is washed out of the villous portion, and the tissue is extracted and purified by hydrochloric acid hydrolysis. The pH is adjusted to 7.0, benzyl alcohol is added, and the filled ampoules are sterilised with high-pressure steam.
The product must not be given to anyone with a history of hypersensitivity to it or to other drugs. The prescribing information lists chills, nausea, fever, redness and rash, and pain or redness at the injection site. Shock is listed as a serious side effect.
Tell the doctor about drug allergies, medical conditions, pregnancy or breastfeeding before an injection.
In Melsmon, placenta means human placenta digested with hydrochloric acid, leaving the water-soluble part that is made into an injectable solution.
The prescribing information states that screening and inactivation cannot remove the risk of transmitting infection completely. No transmission of variant Creutzfeldt-Jakob disease (vCJD) from this product has been reported, but a theoretical risk cannot be ruled out.
No. A 2025 review in Frontiers in Pharmacology reports that human placental extracts from different makers are produced by different methods, so their compositions differ.
Melsmon is made from human placenta, which Japan classes as a specified biological product. The prescribing information therefore requires the clinic to record the drug name, lot number, date of use and patient details, and keep the record for at least 20 years so the product can be traced.
The price depends on the model and the quantity.
This information is for general knowledge and does not replace a doctor's advice. Every procedure should be performed by a licensed doctor in a medical facility.